Colloidal compound of antimony sulphide



UNITED STATES PATENT OFFICE.

MARI E. woLvEKAMr, or OAKLAND, CALIFORNIA.

GOLLOIDAL COMPOUND OF ANTIMONY SULPHIDE.

No Drawing.

T 0 all whom it may concern:

Be it known that I, MARI E. "W LVEKAMP, a subject of the Queen of the Netherlands, and a resident of the city of Oakland, in the county of Alameda and State of California, have invented certain new and useful Colloidal Compounds of Antimony Sulphide, of which the following is a specification. I

My invention relates to the soluble stable combinations of the colloidal antimony sulphides with a protective colloidal salt, more particularly those protective colloid salts known as protallnuninates and lysalbuminate I which are obtained from serum albumin, egg albumin or casein, for medical purposes, and my invention also relates to the process of manufacturing these products herein described and claimed.

The foremost object of my invention is to provide colloidal antimony sulphides which will be stable enough to allow of their solutions being sterilized by boiling and which may be obtained as dry solids without dialyzing.

As a protective colloid the sodium salt of a protalbmic or a lysalbinic acid was found very suitable.

eretofore there have been no suitable colloidal preparations of these sulphides which could be transported in the dry form and which could be readily redissolved.

F. L. Usher (see reference in Chem. Abstr. Am. Chem. Soc, p. 8271, 1919) found solu tions of the sulphide, 1:500 very stable in combination with gum arabic, but states that Paals protalbic acid method is inapplicable to antimony compounds.

Sir Leonard Rogers (see Lancet p. 505, 1919) uses for intravenous injections in kala-azar dilute and previously dialyzed solutions of antimonious sulphide in combination with gum arabic.

Vhereas antimony is highly toxic to trypanosomes and tartar emetic is said to be specific as a treatment for Leishmaniosis of children, readily soluble colloidal antimonious sulphide is in a very suitable form for therapeutic experimentation on such diseases.

In veterinary practice sodium sulphantimonate or Schlippes salt is extensively used and a colloidal antimony pentasulphide without the useless or even harmful sodium sulphide is now rendered available by my invention as a suitable compound for similar cases.

Specification of Letters Patent. Patented A 11 1922 Application filed May 1, 1920. Serial No. 378,230.

combination of antimonious sulphide and protalbinic acid will readily redissolve with an alkaline solution and form a neutral stable solution.

The colors of the hydrosols of the sulphides of antimony are orange-red, whereas the precipitates containing'protalbinic acid are orange-yellow in color.

In the following examples there is taken for each 100 grams of sodium prot-albinate (obtained from serum albumin) one-fifth gram-molecule of tartar emetic for making colloidal antimonious sulphide and one-fifth grammolecule of Schlippes salt for making colloidal antimony pentasulphide.

Example 1: Colloidal antimonious sulphide. Dissolve 100 parts by weight of sodium protalbinate and then add a colorless solution containing 64.6 parts by weight of tartar emetic and 46.8 parts by weight of sodium sulphide and next add 1000 parts by volume of 2N. sulphuric acid, filter, wash the precipitate and redissolve with 1500 parts by volume of 0.1N. sodium hydroxide and finally evaporate at 100 C. Yield: 1032 parts by weight of colloidal combination containing 32.6% antim onious sulphide.

Example 2: Colloidal antimony pentasulphide. Dissolve 100 parts by weight of sodium protalbinate and then add asolution containing 96.0 parts by weight of Schlippes salt and next add 1000 parts by volume of 2N. sulphuric acid, filter, wash the precipitate and redissolve with 2000 parts by volume of 0.1N. sodium hydroxide and finally evaporate at 100 C. Yield: 110 parts by weight of colloidal combination containing 36.4% antimony pentasulphide.

If instead of the 2N. sulphuric acid, there is added a solution containing 21.9 parts by weight of hydrochloric acid and nextadded to this solution three times its volume denatured alcohol and the precipitate dried, a yield is obtained of 75 parts by weight of colloidal combination containing according to analysis 51.4% antimony pentasulphide.

While the preparative methods for the form, it is obvious that modifications and changes can be made without departing from the spirit of the invention or the scope of the claims.

I claim:

1. The soluble combination of a colloidal sulphide of antimony with a protective salt of a protein. 2. The soluble combination of colloid-e1 antimonious sulphide with a protective salt of a protein.

3. The soluble combination of a colloidal binate. I

4. The soluble combination of colloidal ant'ominious sulphide with sodium protalbinate.

5. The combination of a colloidal sulphide of antimony with sodium protalbinate, obtained from serum.

6. Thecombination of colloidal antimonious sul hidevwith sodium'protalbinate obtained rom serum.

MARI E. \VOLVEKAMR 

